Measles Neutralization Antibodies and Some Related Factors in Women of Reproductive-age in Hanoi, Vietnam
Than Huu Dao *
Department of Diseases Control and Prevention, Hanoi Center for Disease Control, Hanoi, No70 Nguyen Chi Thanh street, Dong Da District, Hanoi, Vietnam.
Loan Phuong Do
Department of Virology, National Institute of Hygiene and Epidemiology, No. 1 Yersin Street, Hai Ba Trung District, Hanoi, Vietnam.
Anh Kieu Thi Nguyen
Department of Imaging, Diagnostics and Testing, Hanoi Center for Disease Control, Hanoi, No. 70 Nguyen Chi Thanh street, Dong Da District, Hanoi, Vietnam.
Satoshi Inoue
Department of Veterinary Science, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan.
Katsuhiro Komase
Center for Surveillance, Immunization and Epidemiologic Research (CSIER), National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan.
Hanh Duc Hoang
Faculty of Medical, Dai Nam University, No. 1, Xom Street, Phu Lam, Ha Dong District, Hanoi, Vietnam.
Hien Tran Nguyen
Department of Epidemiology, National Institute of Hygiene and Epidemiology, No. 1 Yersin Street, Hai Ba Trung District, Hanoi, Vietnam.
*Author to whom correspondence should be addressed.
Abstract
Aims: Our study aimed to determine neutralization antibodies against measles virus and some related factors in women of childbearing-age from 18 to 30 years old, in Hanoi, Vietnam.
Methodology: In 2018, a cross-sectional study was conducted on 1,235 childbearing-age women from 18-30 years old in Bavi district, Hanoi, Vietnam. The study participants were interviewed by using a structured questionnaire which included demographic information, and history of measles. The measles neutralization antibodies (MNA) of these participants were quantified by a plaque reduction neutralization test (PRNT). The data were analyzed using the Epidata 3.1 and Stata 14.2 software.
Results: The results showed that only 58.5% had MNA at sufficient protective levels (≥120mIU/ml), up to 12.5% were negative for MNA, and 358 women (29%) had MNA at insufficient protective levels. In addition, we found that the participants’ working as public employees, having two children, and being ≥ 25 years of age were all positively associated with the sufficient protective antibody levels (P<0.05). A weak positive correlation between age and MNA titers was determined (r= 0.26).
Conclusion: Approximately half (41.5%) of the women of childbearing age in this study did not have sufficient protective antibodies against measles virus. The study results suggest that it is necessary to boost measles vaccine to prevent the sporadic measles infection in women of childbearing age in Hanoi and to quantify the dynamics of maternal measles antibody levels in infants born from these women, so as to provide evidences to control measles incidence in children up to 9 months of age in the future.
Keywords: Measles, neutralization antibody, reproductive-age woman, Vietnam