Newly Emerging Candida Specie: Should Clinicians and Mycologist be Concerned?
O. F. Ashcroft *
Department of Medical Microbiology, School of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria.
A. S. Kumurya
Department of Medical Laboratory Science, Faculty of Allied Health Sciences, Bayero University, Kano, Nigeria.
K. Mohammed
Department of Medical Microbiology, School of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria.
M. U. Iduh
Department of Medical Microbiology, School of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria.
A. A. Yusuf
Department of Medical Microbiology, Parasitology and Immunology, Federal Medical Center Yola, Nigeria.
N. M. Bunza
Department of Medical Microbiology, School of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria.
S. U. Nataala
Department of Medical Microbiology, School of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
The emergence of C. auris as a global nosocomial pathogen associated with multidrug resistance and high mortality rates has been recently discovered. This emerging pathogen appears to be far more able to induce systemic infection and mortality than other potential multi drug resistance (MDR) yeast pathogens even though it is found to have reduced virulence factors compared to C. albicans. There are issues with regard to the identification of C. auris using both phenotypic and molecular techniques; this has raised concerns about detecting the true scale of the problem. This mini- review elucidates on the literature available on C. auris and highlights the mechanism of pathogenesis and antifungal resistance, which will give further direction to extensive research in this field.
Keywords: Candida auris, emerging infection, nosocomial pathogens, antifungal susceptibility, pathogenesis.