Effect of Previous Infection and Vaccination on Incidence of Covid-19 among Healthcare Workers and Antibody Response
J. B. Gupta *
Department of Internal Medicine, Eternal Heart Care Centre and Research Institute, Jaipur, 302017, India and Department of Clinical Research, Eternal Heart Care Centre and Research Institute, Jaipur, 302017, India.
R. S Khedar
Department of Internal Medicine, Eternal Heart Care Centre and Research Institute, Jaipur, 302017, India.
Alok Mathur
Department of Internal Medicine, Eternal Heart Care Centre and Research Institute, Jaipur, 302017, India.
Priyansha Jain
Department of Clinical Research, Eternal Heart Care Centre and Research Institute, Jaipur, 302017, India.
Danish Azad
Department of Pharmacology, Eternal Heart Care Centre and Research Institute, Jaipur, 302017, India.
Muskan Madaan
Institute of Clinical Research, Jaipur National University, Jaipur, 302017, India.
Rajeev Gupta
Department of Internal Medicine, Eternal Heart Care Centre and Research Institute, Jaipur, 302017, India and Department of Cardiology, Eternal Heart Care Centre and Research Institute, Jaipur, 302017,India.
*Author to whom correspondence should be addressed.
Abstract
Aims: To correlate the effect of previous COVID-19 infection and vaccination on incidence of COVID -19 infection .
Study Design: It is a prospective observational study.
Place and Duration of Study: Eternal Heart Care Centre and Research Institute, Jaipur, India.
Methodology: We included 405 healthcare workers with COVID-19 positive infection, with or without the symptoms. Clinical as well as hematological examination were done.
Results: Our study showed 75.6% seropositivity rate even 6 months after vaccination in which seropositivity was significantly higher in people who had past history of COVID-19 .Antibody levels were highest when observed one month after vaccination. A decrease in antibody levels over time after vaccination is observed. Seropositivity rate was significantly higher in people who were less than 40 years old.
Conclusion: A decrease in antibody levels over time after vaccination is observed and this showed that the rate of infection decreases after receiving vaccination.
Keywords: Infection, vaccination, Covid-19, healthcare workers, antibody response