Oxygen Dissociation Curve: Reviewing the Physiology and Influencing Factors
Arijit Sil *
IQVIA RDs Ltd. Bengaluru, Omega Embassy Tech Square; Marathahalli- Sarjapur Outer Ring Road, Kadubeesanahalli; Bangalore- 560103, Karnataka, India.
*Author to whom correspondence should be addressed.
Abstract
The oxyhemoglobin dissociation curve is a vital tool for comprehending how blood transports and releases oxygen, that is carried throughout the body both in bound form with protein (hemoglobin) and dissolved in plasma. The oxyhemoglobin dissociation curve describes the relationship of oxygen saturation (SaO2) and partial pressure of oxygen in the blood (PaO2) (Patel & Jose 2024).
The oxygen dissociation is affected by factors like pH, CO2, 2,3-DPG, CO. This paper discusses the significance of factors like pH, CO2, 2,3-DPG, CO, and structurally different haemoglobin which have a considerable effect on the affinity of haemoglobin for oxygen and determine how efficiently oxygen is supplied to the body cells.
Keywords: Oxygen dissociation curve, oxygen binding affinity, Bohr effect