Prevalence of COPD Exacerbation with Type-2 Diabetes Comorbidity: A Systematic Review and Meta-Analysis
Armita Dewi *
Departement of Pulmonologi and Respiratory Medicine, Faculty of Medicine, University of Hasanuddin, Wahidin Sudirohusodo Hospital, South Sulawesi, Indonesia.
Nirwana Fitriani Walenna
Departement of Pulmonologi and Respiratory Medicine, Faculty of Medicine, University of Hasanuddin, Wahidin Sudirohusodo Hospital, South Sulawesi, Indonesia.
Faisal Yunus
Departement of Pulmonologi and Respiratory Medicine, Faculty of Medicine, University of Indonesia, Persahabatan Hospital, Jakarta, Indonesia.
Nur Ahmad Tabri
Depertement of Anatomy, Faculty of Medicine, University of Hasanuddin, South Sulawesi, Indonesia.
Irawaty Djaharuddin
Departement of Pulmonologi and Respiratory Medicine, Faculty of Medicine, University of Hasanuddin, Wahidin Sudirohusodo Hospital, South Sulawesi, Indonesia.
Arif Santoso
Departement of Pulmonologi and Respiratory Medicine, Faculty of Medicine, University of Hasanuddin, Wahidin Sudirohusodo Hospital, South Sulawesi, Indonesia.
Muhammad Ilyas
Departement of Pulmonologi and Respiratory Medicine, Faculty of Medicine, University of Hasanuddin, Wahidin Sudirohusodo Hospital, South Sulawesi, Indonesia.
*Author to whom correspondence should be addressed.
Abstract
Background: Type-2 Diabetes Mellitus (type-2 DM) is one of the comorbidities in Chronic Obstructive Pulmonary Disease (COPD), associated with the incidence of respiratory tract infections which is a risk factor for COPD exacerbations.
Methods: Systematic review include publications from January 1st 2015 to October 31th 2021, using data base Pubmed and Google Scholar and meta-analysis conducted to summarize prevalence of COPD exacerbation with type-2 DM with subgroup analysis base on geographical location, study design, study period also characteristic population COPD exacerbation with type-2 DM comorbidities.
Results: Seven studies conducted in the meta-analysis. Pooled prevalence of COPD exacerbations with type-2 DM comorbidity was 34.22% (95%CI: 27.49%-41.28%) and heterogeneity (I2=87.69%, Q=48.75, p=<0.001). Five studies were based in Europe, one study in Asia and the Americas.
Prevalence of COPD exacerbations with type-2 DM comorbidity based on WHO region subgroup analysis found European region 34.70% (95%CI:25.88%-43.96%), America’s region 40.28% (95%CI: 39 .89%-40.79%) and the Western Pacific region 26.01%(95%CI:0.20;0.32) with statistical heterogeneity (I2 = 77%, Q=17.63, p=<0.001). Population age of the study was above 60 years and more males than females (n=30,58.8% vs n=21,41.1%). Most common other comorbidities of COPD exacerbation were hypertension, obesity, and coronary heart disease.
Conclusion: Pooled prevalence of COPD exacerbations with comorbid type-2 DM in this systematic review and meta-analysis was 34.22% (95%CI: 27.49%-41.28%)
Keywords: COPD, diabetes mellitus, comorbid disease