Retrospective Analysis of Rifampicin-resistance Pattern of Mycobacterium tuberculosis among Presumptive Tuberculosis Patients in Secondary Referral Hospital Offa, Nigeria
Pelumi Daniel Adewole *
Department of Medical Laboratory Science, School of Basic Medical Science, College of Pure and Applied Sciences, Kwara State University, Malete Kwara State, Nigeria.
Muhammed Usman
General Hospital, Offa, Kwara State, Nigeria.
Maroof Gbadebo Oyeniyi
General Hospital, Offa, Kwara State, Nigeria.
Damilola Kazeem Suleman
Department of Medical Laboratory Science, Nigeria Navy School of Health Sciences, Offa, Nigeria.
Olayemi Olubunmi Alaka
Department of Medical Microbiology and Parasitoloy, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria.
Ibukun Adeola Adetoro
Africa Regional Centre for Information Science, University of Ibadan, Nigeria.
Olumiyiwa Samuel Alabi
Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Ibadan, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Introduction: Early detection of drug resistant tuberculosis with more sensitive and accessible method together with appropriate control measures among other factors are keys to interruption of transmission and mortality rate.
Study Design: This study conducted a retrospective review of presumptive TB register of patients screened for Mycobacterium tuberculosis (MTB) and rifampicin resistant tuberculosis (RR-TB) using Xpert MTB/RIF assay at General Hospital Offa in Kwara State Nigeria between January to December 2018 in order to access the on-going efforts such as quarterly surveillance, improved infrastructural facilities and intense media advocacy on Tuberculosis by Kwara state government on prevention of Tuberculosis in Kwara State.
Results: Overall, 63 (10.6%) of the sputum samples collected were positive for Mycobacterium tuberculosis while 4 (6.3%) showed rifampicin resistance out 63 (10%) of patients positive for Mycobacterium tuberculosis. There is high recovery rate of Mycobacterium tuberculosis among women than men as this study recovers 52.4% and 47.6% in male and female respectively. Adults appear to be more vulnerable to TB and the vulnerability tends to increase with age.
Conclusion: This study documents low frequency of rifampicin resistance tuberculosis particularly within female population using highly sensitive and specific Xpert MTB/RIF in Kwara State.
Keywords: Retrospective, rifampicin resistance, Mycobacterium tuberculosis, Offa.