https://www.journalajrid.com/index.php/AJRID <p style="text-align: justify;"><strong>Asian Journal of Research in Infectious Diseases (ISSN: 2582-3221)</strong> aims to publish&nbsp;high-quality&nbsp;papers (<a href="/index.php/AJRID/general-guideline-for-authors">Click here for Types of paper</a>) in all aspects of&nbsp;‘Infectious Diseases’. By not excluding papers based on novelty, this journal facilitates the research and wishes to publish papers as long as they are technically correct and scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled, OPEN peer-reviewed, open-access INTERNATIONAL journal.</p> Asian Journal of Research in Infectious Diseases en-US Asian Journal of Research in Infectious Diseases 2582-3221 https://www.journalajrid.com/index.php/AJRID/article/view/553 <p><strong>Background</strong>: Cytotoxic lesions of the corpus callosum (CLOCCs) are increasingly recognised as reversible neuroradiological abnormalities associated with diverse infectious and inflammatory conditions. However, their occurrence in bacterial infections, particularly typhoid fever, remains exceedingly uncommon and poorly documented in the literature.</p> <p><strong>Aim</strong>:&nbsp;To report a rare case of cytotoxic lesions of the corpus callosum (CLOCCs) associated with typhoid infection and to highlight its reversible radiological nature in infectious encephalopathies.</p> <p><strong>Presentation of Case:</strong>&nbsp;Cytotoxic lesions of the corpus callosum (CLOCCs) are transient MRI abnormalities, most commonly involving the splenium of the corpus callosum, and are associated with infections, seizures, metabolic disturbances, drug toxicity, and autoimmune disorders. Viral infections are the most frequently reported infectious causes. Proposed mechanisms include cytokine-mediated cytotoxic edema and reversible inflammatory injury affecting densely myelinated splenial fibers. Clinically, patients may present with altered sensorium, delirium, encephalopathy, or seizures, often posing a diagnostic challenge. We report a rare case of CLOCCs occurring in a patient with typhoid encephalitis.</p> <p><strong>Discussion:</strong>&nbsp;Typhoid fever caused by Salmonella typhi commonly presents with systemic manifestations, whereas neurological involvement such as encephalopathy is uncommon. The occurrence of CLOCCs in typhoid encephalitis is exceedingly rare and sparsely described in literature. Recognition of this characteristic MRI pattern is important to avoid unnecessary invasive investigations and to support timely diagnosis of the underlying infectious etiology.</p> <p><strong>Conclusion:</strong>&nbsp;CLOCCs should be considered in patients with acute febrile encephalopathy and reversible splenial lesions on MRI. Early recognition and appropriate treatment of the underlying infection are associated with favorable neurological and radiological recovery.</p> P. Dineshkumar M. Shashank Vishaalpalaniswamy Ramaswamy Sanjeevi Kumar Krishnan Anumantharaj S. Shivamalarvizhi Murugan K Ravindran T. B. Uma Devi Copyright (c) 2026 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 2026-05-29 2026-05-29 17 6 1 7 10.9734/ajrid/2026/v17i6553